Does THC Increase Serotonin? Let's Unpack the Facts!

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We know this is a burning question for many (including for us).. Does THC impact or increase serotonin? Well, you have come to the right place, because in this blog we are deep diving into all things cannabis and serotonin. It doesn't matter if you are a cannabis vet or if this is your first rodeo, we are going to break down the science and evidence available surrounding this issue, and hopefully have a bit of fun along the way!

Key Takeaways:

  • THC and the Brain: THC (tetrahydrocannabinol) interacts with the brain's endocannabinoid system, which plays a role in regulating mood, appetite, and pain.
  • Serotonin 101: Serotonin is a neurotransmitter that contributes to feelings of well-being and happiness. It's often referred to as the "feel-good" chemical.
  • Research Insights: Some studies suggest that THC can briefly increase serotonin levels, but the effects are complex and can vary.
  • Short-term vs. Long-term: While short-term use of THC might boost serotonin, long-term or excessive use can potentially lead to a decrease in serotonin production, leading to mood imbalances.

The Buzz About THC and Serotonin

Firstly, what is all the hoopla about? As many people know, cannabis has a main component called tetrahydrocannabinol, most commonly referred to as THC. THC is psychoactive, and is what makes people feel "high". Serotonin is a neurotransmitter (a type of hormone) that is in our bodies, and our brains, and makes us feel good - in fact, it is often referred to as the happy hormone.

So, how does THC and serotonin interact? Does THC affect Serotonin? Read on to get the A's to these Q's!

The Science Behind It All

A Quick Brain Chemistry Lesson

Before we get too far, it helps to know a little bit about how our brains work. Serotonin is a chemical messenger that helps transmit signals between nerve cells. It's often called the "feel-good" neurotransmitter because it contributes to feelings of well-being and happiness.

THC primarily interacts with the endocannabinoid system (yes, your body has one of those!), which plays a role in regulating a variety of physiological processes, including mood and stress.

How THC Interacts with Serotonin

Research suggests that THC doesn’t directly increase serotonin levels. Instead, it interacts with the brain's cannabinoid receptors, which can indirectly affect serotonin pathways. Think of it as THC throwing a pebble into a pond—the ripples eventually reach serotonin, but it's not a direct hit.

The Indirect Boost

When THC activates cannabinoid receptors, it leads to the release of dopamine, another neurotransmitter associated with pleasure and reward. This chain reaction can result in a temporary improvement in mood, which might explain why some people feel happier and more relaxed after using cannabis.

The Catch

Here’s a twist: while THC can have immediate mood-boosting effects, heavy or prolonged use can potentially lower serotonin levels over time. Some studies indicate that chronic cannabis use might be linked to long-term changes in brain chemistry, including serotonin regulation. Like everything in life, moderation is key!

What This Means for You

Occasional Users

If you’re someone who enjoys cannabis occasionally, you're likely to experience the mood-enhancing benefits without significant dips in serotonin levels. The key is balance and being mindful of your usage.

Regular Users

For those who use cannabis more frequently, it might be worth paying attention to how it affects your mood over time. If you notice changes in your mental health, it could be related to serotonin levels, and it might be wise to take a step back and evaluate your usage.

The Role of Individual Differences

Everyone's brain chemistry is unique, so THC will affect people differently. Factors like genetics, mental health history, and even diet can influence how cannabis impacts your serotonin levels.

Listening to Your Body

The best advice? Listen to your body. If you’re using cannabis and feel great, that’s awesome! If you start to notice negative changes, it might be time to reassess your relationship with THC.

Who Should Avoid THC?

THC definitely is not for everyone, and there are many risks to consuming THC. The groups of people that may want to be extra cautious and completely steer clear of any THC/cannabis products are:

Pregnant or Breastfeeding Individuals

More evidence now indicates that THC consumption (by a pregnant woman or a breastfeeding mother) can negatively impact fetal and baby development.

Individuals with a History of Mental Health Issues

If you have a history of mental health conditions such as anxiety, depression, or schizophrenia, THC is not be for you. While some people find relief from symptoms using cannabis, others might experience exacerbation of their conditions. Always consult with a healthcare provider if you have a history of mental health issues before using THC.

Adolescents and Young Adults

Did you know that the brain continues to develop until you're about 25 years old? This is why is critical that younger people and children avoid THC. Research indicates that substance use (including cannabis) and alcohol use can negatively impact a developing brain. So, if you're under 25, it is best to avoid THC consumption. 

Individuals with a History of Substance Abuse

THC may be habit-forming, especially for those with a history of substance abuse. If you fall into this category, it’s wise to approach THC with caution. Consulting a healthcare professional before starting any THC regimen is a good idea.

People Who Must Undergo Drug Testing

Some jobs and activities require regular drug testing, and THC can stay in your system for a long time. If you're subject to these tests, it's best to avoid THC to prevent any potential complications.

Remember, everyone’s relationship with THC is unique. Always take into account your personal circumstances and consult with healthcare professionals when in doubt.

What about CBD...Does CBD Increase or Decrease Serotonin?

Alright, let's switch gears and talk about another superstar in the cannabis world: CBD, or cannabidiol. If you're wondering whether CBD could have an impact on your serotonin levels, you're not alone. Grab a comfy seat because we're about to explore this fascinating topic together.

The Basics of CBD

Unlike THC, CBD is non-psychoactive, meaning it won't give you the "high" that THC is known for. But don't let that fool you into thinking it's any less interesting! CBD has garnered attention for its potential therapeutic effects, from easing anxiety to relieving pain.

How CBD Interacts with Serotonin Receptors

Here’s where it gets interesting—CBD has a unique way of interacting with the brain. Rather than directly impacting serotonin levels, CBD is believed to influence serotonin receptors in the brain, particularly the 5-HT1A receptor. This receptor is linked to mood regulation and anxiety, which is why CBD is often touted for its calming effects.

The Potential Benefits

Some research suggests that CBD may help increase the availability of serotonin by interacting with these receptors. This could potentially make you feel more relaxed and uplifted, much like how well-regulated serotonin would.

The Subtle Differences

However, the way CBD influences serotonin is more indirect compared to THC. It might not give you an immediate "boost," but over time, it could contribute to a better sense of well-being. This makes CBD a popular choice for those seeking a natural and gentle way to support their mental health.

The Personal Touch

As always, your mileage may vary. The effect of CBD on serotonin can differ from person to person, depending on factors like your body chemistry, genetics, and even your overall health.

Final Thoughts: Stay Curious

The connection between THC and serotonin is a fascinating topic with plenty of ongoing research. While we don’t have all the answers yet, staying informed and curious is the best way to navigate your cannabis journey.

Remember, it’s all about finding what works best for you. As always, if you have any concerns about your mental health or substance use, it’s a good idea to talk to a healthcare professional.

Feel free to share your thoughts and experiences in the comments below. We love hearing from you!

Stay happy and healthy!


What Depletes Serotonin?

Moving beyond THC and serotonin, into a more general mental health convo... what other factors can contribute to and potentially drain your serotonin levels? Well, there are a few key areas to look at to help you maintain serotonin levels so you can stay as happy as ya can!

Stress and Anxiety

This is a big one, especially because of the nature of the high-paced world we live in. Stress, in particular chronic stress or underlying anxiety issues can be contributors and lead to low levels of serotonin. 

Poor Diet

Often overlooked when it comes to mental health is diet. "You are what you eat" is the saying, right? A well-balanced diet provides your body with the building blocks (amino acids, vitamins and minerals) from which it can make serotonin.

Lack of Sunlight

Ever heard of the “winter blues”? That's partly because decreased exposure to sunlight in the winter months can lower your serotonin levels. Your body needs sunlight to synthesize vitamin D, which in turn helps produce serotonin. So, getting outside for a bit of sun can be a natural mood booster.

Sleep Deprivation

Catching those Z’s is more important than you might think. A lack of sleep can disrupt your brain’s ability to produce serotonin, leading to grumpiness, irritability, and overall mood downturns. Aim for a consistent sleep schedule and quality rest to keep serotonin levels in check.

Substance Abuse

Overuse of substances like alcohol, drugs, and even certain medications can interfere with your brain's serotonin levels. While these might offer temporary relief or pleasure, they can lead to a significant drop in serotonin once the effects wear off. Moderation is key, and if you’re struggling, seeking help from a professional is always a good option.

Sedentary Lifestyle

Get that body moving! Too many of us live a sedentary lifestyle, meaning we are still, too much! Movement and exercise are big contributors when it comes to increasing feel-good hormones like serotonin. It does not need to be an intense work out class either! Try forms of exercise you actually like to do, like a walk in nature, playing basketball, tennis, or even rock climbing.

Negative Thought Patterns

What you think affects how you feel. If you are constantly in a cycle of negative thinking, this can affect your mood and hormone levels (i.e. serotonin). Try journaling to become aware of your thoughts, and potentially how you can reframe things into a more positive light. Techniques like mindfulness meditation can also be helpful.

Medical Conditions

There are definitely medical conditions that impact serotonin levels and production, including clinical depression, anxiety, and chronic pain. 

It is important to be mindful of these factors and make adjustments if necessary.

None of what is written on is intended to be medical advice. Consult your health care practitioner with any medical concerns or questions you may have. 


1) Nadeem Z, Wu C, Burke S, Parker S. Serotonin syndrome and cannabis: A case report. Australas Psychiatry. 2024 Feb;32(1):100-101. doi: 10.1177/10398562231219858. Epub 2023 Dec 6. PMID: 38058145; PMCID: PMC10809727.

2) Franklin JM, Mathew M, Carrasco GA. Cannabinoid-induced upregulation of serotonin 2A receptors in the hypothalamic paraventricular nucleus and anxiety-like behaviors in rats. Neurosci Lett. 2013 Aug 26;548:165-9. doi: 10.1016/j.neulet.2013.05.039. Epub 2013 May 27. PMID: 23721787; PMCID: PMC3735609.

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