Is CBG Good for Pain? Everything to Know

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Disclaimer: None of what is published on evn-cbd.com is intended to be professional medical advice. Consult your health practitioner regarding any medical treatment or diagnosis.

With the popularity of cannabis-based wellness products on the rise, interest in up-and-coming cannabinoids like CBG is skyrocketing. CBG is a relative newcomer to the cannabis scene, and many may be wondering if it can offer a respite from pain. The latest research suggests CBG has exciting therapeutic potential, ranging from chronic pain to helping with neurological conditions.

This article will take a deep dive into the potential benefits of CBG for pain, providing you with the latest findings from scientific studies, the pros and cons of its use, and some handy tips to help you navigate this new landscape. 

Key Takeaways:

  • CBG is the chemical precursor to THC and CBD and serves as the third-most abundant cannabinoid found in marijuana and hemp.
  • CBG is relatively unresearched, but emerging evidence suggests that it may have anti-inflammatory properties and some positive effects on reducing nerve pain.

What is CBG?

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Known as the "parent" cannabinoid, cannabigerol (CBG) is the third-most abundant chemical and is integral to the existence of other smaller cannabinoids found within the Cannabis sativa plant. 

CBG's acidic version, cannabigerolic acid (CBGA), serves as the chemical precursor for THCA and CBDA. These precursors transform into THC and CBD when exposed to heat or air. This transformation into a consumable form happens through heat exposure, as seen when one smokes a pre-roll or vaporizes it. 

Naturally present in cannabis and hemp plants, CBG is more common in young cannabis plants before their eventual conversion into other cannabinoids. As the plants age, the production of CBG diminishes. 

How CBG works

The precise mechanisms that rule the interaction between CBG and our bodies' endocannabinoid system (ECS) require further exploration. However, the present studies on CBG show both its pain-relieving potential and mood-enhancing properties. 

The human body's endocannabinoid system processes CBG similarly to how we process other cannabinoids. Unlike THC, however, it doesn't produce any euphoric effects.

One exciting aspect of CBG's interaction with the endocannabinoid system is its potential ability to mitigate the psychoactive effects of THC. By competing with THC for the same occupancy at CB1 receptors, CBG can potentially make THC less intoxicating and reduce the risk of overwhelming users with potency. Interestingly, however, while it reduces the impact of THC, CBG might also extend THC's duration in the body. 

It's crucial to understand that while CBG does not intoxicate, its presence in the body does have physical effects. Notably, many of these effects are linked to potential health benefits.

CBG and Pain

Due to cannabis’ status as a Schedule I restricted substance, the clinical evidence of CBG’s impact on humans, especially on pain, is limited. Regardless, animal studies suggest that CBG may provide relief from nerve pain and other pain-related issues.

Potential Benefits

One study found that long-term use of CBG helped attenuate chronic nerve pain, providing at least 24 hours of relief and no development of tolerance in animal models. Another study found that CBG helped ease neuropathic pain throughout the body with no observable side effects.

CBG also seems to have potential anti-inflammatory properties, which could be helpful in chronic pain and the recovery of injuries or arthritis. In one study, derivatives of CBG significantly reduced inflammation while also relieving the experience of pain.

Studies also suggest that CBG might have neuroprotective effects. This means it could help protect your nerve cells from damage, inflammation, and dysfunction - a crucial aspect in managing chronic pain conditions like multiple sclerosis (MS).

Risks and Drawbacks

While there is increasing interest in using CBG for managing pain, it's important to weigh both the potential benefits and drawbacks.

Firstly, the lack of substantial human-centric scientific research means we need more evidence about CBG's effects on the body. Preliminary findings suggest benefits, but these are largely based on laboratory studies and animal models. Optimal dosages and long-term effects are still unclear. 

Like other cannabinoids, CBG could interact with certain medications, potentially altering their efficacy or causing adverse side effects. Discussing usage with a healthcare provider is essential if you are on any medication. 

Finally, CBG is typically found in low concentrations in most cannabis strains, making it more challenging and costly to extract. This often translates to higher prices for CBG products, which may not be worth the cost compared to the more affordable CBD.

The Bottom Line: Should You Use CBG for Pain?

Current research shows promising results when it comes to using CBG for pain management, but don't forget to consider both the pros and cons and ensure you're using CBG safely and effectively. 

Remember, every individual's experience with CBG may vary, so it may take some trial and error to find what works best for you. A knowledgeable conversation with your healthcare provider can be beneficial before embarking on your CBG journey.

If you’re ready to get started using CBG for managing neuropathic pain, look no further than Evn’s CBG gummies.

Sources

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  2. Calapai, F., Cardia, L., Esposito, E., Ammendolia, I., Mondello, C., Lo Giudice, R., Gangemi, S., Calapai, G., & Mannucci, C. (2022). Pharmacological aspects and biological effects of cannabigerol and its synthetic derivatives. Evidence-based Complementary and Alternative Medicine, 2022, 1–14. https://doi.org/10.1155/2022/3336516
  3. Nachnani, R., Raup‐Konsavage, W. M., & Vrana, K. E. (2020b). The pharmacological case for cannabigerol. Journal of Pharmacology and Experimental Therapeutics, 376(2), 204–212. https://doi.org/10.1124/jpet.120.000340
  4. Nachnani, R., Sepulveda, D. E., Booth, J., Zhou, S., Graziane, N., Raup‐Konsavage, W. M., & Vrana, K. E. (2023). Chronic cannabigerol as an effective therapeutic for Cisplatin-Induced neuropathic pain. Pharmaceuticals, 16(10), 1442. https://doi.org/10.3390/ph16101442
  5. Sepulveda DE, Morris DP, Raup-Konsavage WM, Sun D, Vrana KE, Graziane NM. Cannabigerol (CBG) attenuates mechanical hypersensitivity elicited by chemotherapy-induced peripheral neuropathy. Eur J Pain. 2022 Oct;26(9):1950-1966. doi: 10.1002/ejp.2016. Epub 2022 Aug 4. PMID: 35899583.
  6. di Giacomo V, Chiavaroli A, Recinella L, Orlando G, Cataldi A, Rapino M, Di Valerio V, Ronci M, Leone S, Brunetti L, Menghini L, Zengin G, Ak G, Abdallah HH, Ferrante C. Antioxidant and Neuroprotective Effects Induced by Cannabidiol and Cannabigerol in Rat CTX-TNA2 Astrocytes and Isolated Cortexes. Int J Mol Sci. 2020 May 18;21(10):3575. doi: 10.3390/ijms21103575. PMID: 32443623; PMCID: PMC7279038.

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