The Best Terpenes for Pain and Inflammation Relief

yellow leaves on cannabis plant

Are you on the lookout for natural solutions to manage pain and inflammation? If so, it may be time to turn your attention towards terpenes.

While not unique to cannabis, terpenes are essential oils found in high concentrations within hemp and marijuana plants. Research suggests that certain terpenes, like myrcene, beta-caryophyllene, and linalool, can effectively relieve pain and reduce inflammation. But which strains of cannabis contain these power-packed terpenes? 

In this guide, we explore the best terpenes for pain and inflammation relief and delve into the strains that are rich in these compounds to help you navigate your path to natural, efficient, and holistic pain management. 

Key Takeaways:

  • Terpenes such as myrcene, beta-caryophyllene, and linalool have a strong potential to manage pain and inflammation, individually and combined.
  • Research continues to reveal how these naturally occurring aromatic compounds can ease pain and inflammation.
  • It's important to experiment responsibly to find the most effective terpene or blend, understanding that each body responds differently. 

strawberry ring


How Terpenes Affect Pain and Inflammation

While the exact mechanisms aren't fully understood, terpenes are thought to act on certain receptors in the body's endocannabinoid system (ECS) to produce their therapeutic properties. The ECS is present in all humans and animals and regulates homeostasis in mood, appetite, stress response, sleep, and – most importantly – pain and immune response.

Despite missing research, a large body of evidence suggests that certain terpenes can alleviate pain, including the following that we explore in further detail.


Myrcene is one of the most abundant terpenes found in cannabis and hemp plants, present in over 40% of known cannabis strains. It produces hints of spicy, musky, or earthy notes and is found in various other plants and fruits — from lemongrass and eucalyptus to mangoes and beyond. 

Research suggests that myrcene has potent analgesic and anxiety-reducing properties, making it a helpful tool for targeting muting pain sensations and easing stress-related inflammation. Studies also indicate that myrcene, combined with THC, produces an entourage effect of improved therapeutic benefits in pain and inflammatory relief. 

Strains like Bubba Kush (found in our Indica THC gummies), OG Kush, Jack Herer, and Blue Dream all contain naturally high-occurring levels of myrcene.

bubba kush gummies



Linalool is a floral terpene responsible for whenever cannabis strains have more floral, spicy, or even woody notes. Research shows that linalool has calming properties, potentially offering relief from anxiety and depression. In cannabis, alongside other relaxing terpenes like myrcene and humulene, linalool might further enhance this tranquility.

Besides serving as a primary terpene in cannabis, linalool also plays a significant role in many other areas. Its scent and properties are often incorporated into personal care products and food items like lotions or teas. The essential oil infuses cosmetics, perfumes, and other skincare products with a delightful scent that relaxes the senses and produces a sense of tranquility. Not only that, linalool reportedly offers antimicrobial and anti-inflammatory advantages.

A noteworthy clinical study from 2007 evaluated the effect of linalool aromatherapy on post-surgical patients. The findings of the study revealed that patients who were administered linalool-based aromatherapy needed fewer opioids during their immediate recovery phase. Another 2021 research review found that linalool blocks pain through both central and peripheral mechanisms, which makes it a great candidate for those seeking to relieve the sensation of pain.

Some common cannabis strains that have this terpene include Lavender, Trainwreck, Amnesia Haze, and LA Confidential.


Beta-caryophyllene boasts a fragrance that's an intriguing mix of spicy pepper dashed with a hint of cinnamon. It occurs naturally in herbs such as rosemary, cloves, hops, and black pepper, among others. 

As previously mentioned, terpenes work by activating cell receptors in the ECS. Beta-caryophyllene is unique because it is the sole compound research has found to directly activate CB2 receptors, primarily located in the central nervous system (CNS) and the peripheral immune system. This finding opens the door to theories that other terpenes may work similarly to impact mood, pain, and stress. In scientific reviews, beta-caryophyllene is well-known for its pain-relieving and anti-inflammatory properties.

Generally, if you're looking for strains rich in caryophyllene, any strain in the "Cookies" family is a safe bet. Some other options include Sour Diesel, Hawaiian Haze (like you'll find in our Sativa Delta-9 Gummies), Bubba Kush, Sour Space Candy, Special Sauce, and Gelato.

strawberries floating with a package


The Bottom Line

Understanding how terpenes like myrcene, beta-caryophyllene, and linalool can impact pain and inflammation management is crucial in maximizing the therapeutic benefits of your choice strains. Increasingly positive research data reveals how these aromatic compounds can provide significant relief. 

Whether they're employed individually or synergistically with cannabis and each other, the healing potential is significant. Remember, everyone's body is unique, so your mileage may vary. Stay informed, experiment responsibly, and find the best combination. 

Get started exploring terpenes for pain relief with our selection of hemp-derived cannabis products.

Disclaimer: None of what is published on is intended to be professional medical advice. Consult your health practitioner regarding any medical treatment or diagnosis.

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